[Frontiers in Bioscience 11, 126-135, January 1, 2006] 126 Stem cell factor (SCF)-Kit mediated phosphatidylinositol 3 (PI3) kinase signaling during mammalian oocyte growth and early follicular development
نویسنده
چکیده
1. Abstract 2. Introduction 3. SCF, Kit and the PI3 kinase pathway 3.1. Kit and Kit ligand SCF 3.2. PI3 kinase 3.3. Akt and its activation 3.4. The FOXO subclass of forkhead box transcription factors 4. Kit-PI3 kinase signaling in mammalian oocytes 4.1. Kit and SCF in the mammalian ovary 4.2. Activation of the oocyte PI3 kinase pathway in mouse and rat oocytes by SCF 5. Mutant mouse models for the study of Kit-PI3 kinase pathway in oocytes 5.1. Spontaneously occurred Kit or SCF mutant mice 5.2. Kit Y719F mutant mice 5.3. Foxo3a deficient mice 5.4. GDF-9 deficient mice 6. Perspective 7. Acknowledgement 8. References
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